Cynomel

Cynomel is a synthetically form of the natural thyroid hormone 3, 5, 3’ triiodothyronine, which has all the pharmacological activities of the natural substance.
Clinically, Cynomel had been often utilized in efforts to have treated Hypothyroidism, which is a thyroid insufficiency, as well as other secondary symptoms
such as obesity, metabolic disorders, and fatigue. Thyroid hormones had been characteristically believed to have been able to have exerted most of their
actions through the control of protein synthesis. When moderate amounts of Thyroid hormones had been administered, they had been able to have increased
the synthesis of RNA and protein, which had often been followed by an increased basal metabolic rate; as well as having stimulated the oxidative enzyme systems.
This, in turn, had enhanced the release of free fatty acids from adipose tissue, and had increased the intestinal absorption and peripheral utilization of
glucose. When higher concentrations had been apparent, this had generally resulted in the decrease of protein synthesis, and in the increase of the breakdown
of glycogen, lipids and protein.
The Cynomel compound closely had resembled the natural thyroid hormone, Tricodide-thyronine (L-T3), and under normal circumstances, the thyroid usually had
produced two hormones, L-thyroxine (L-T4) and L4riiodine 4hyronine (L-T3). However, the latter hormone, had been much stronger and more effective of the two,
and had been approximately 4 times as potent as L-T4 on a weight basis.
When Cynomel had been administered orally, it had been readily available to the body tissue with approximately 95% of the dose being absorbed within 4
hours from the gastrointestinal tract. The biological half-life of Cynomel had been approximately two and a half days, with the maximal pharmacological
response having occurred within 2 or 3 days. This characteristic had also provided for an early clinical response, as the onset of activity had usually retired
within a few hours.

Several self-administering athletes had generally claimed that the synthetic compound of Cynomel had been able to have produced the same processes in the
body, as if the thyroid had been able to have to produced more of the hormone. Consequently, this entity had allowed Cynomel to have been more effective
than the compound of Eutirox or Tiroidine,56, which had been other commercially available L-T4 compounds that had been currently available in Mexico.
Many athletes had taken advantage of these characteristics, which had been able to have stimulated the metabolism, which in turn, had resulted in a faster conversion
of the macronutrients of carbohydrates, proteins, and fats. Bodybuilders, had been especially interested in increased fat burning (lipolysis) entities of the
compound of Cynomel. Cynomel had been often utilized by competing bodybuilders several weeks prior to competition, as it had aided in having maintained
an extremely low fat content, without the extremes of a starvation diet. This distinctive feature also had made it very popular amongst female athletes, due to the
fact that women generally had slower metabolisms than men. Administration of Cynomel had allegedly allowed for the ridding of bodyfat, without a drastic
caloric restriction. This also had many athletes to have been able to have remained on high calorie diets with the added advantage of having maintained a
“ripped” appearance. Athletes who had utilized Cytomel over several weeks, often had experienced a decrease in muscle mass, which had been discovered to
have been avoidable or at least delayed, by the simultaneous intake of steroidal compounds, and by the consumption of a protein rich diet.
Another advantage, which several athletes who had administered low dosages of Cynomel had claimed to have experienced, had been that the simultaneous
intake of steroidal compounds had appeared to have become more effective. This possibly may have occurred as a result of the faster conversion of protein.
Although some athletes still had utilized the administration of Cynomel, it had not been nearly as popular as it had once appeared to have been. Spiropent,
and Ephedrine (the latter is currently not available in Mexico), had emerged to have had employed the same accelerating metabolism effects, with other added
advantages such as possible strength and muscle increases. The combination however, of Cynomel and Spiropent, or Ephedrine (the latter is currently not available
in Mexico), had allegedly appeared to have had enormously accelerated lipolysis